Inhibitory effects of a novel nutrient mixture on MMP secretion and invasion on human thyroid cancer cell line SW 579

In this study, we investigated the effect of NM on a thyroid cancer cell line on proliferation (MTT assay), MMP secretion (gelatinase zymography, Matrigel invasion, and morphology (H&E). Zymography demonstrated that NM inhibited MMP-2 secretion, with virtually total inhibition at 1000 μg/ml. Matrigel invasion was inhibited at 50, 100, and 500 μg/ml by 42%, 63% and 100% respectively. NM was nontoxic to thyroid cancer cells below 500 μg/ml and H&E staining did not show morphological changes.

Key Words
Thyroid cancer, MMPs, Matrigel™ invasion, nutrients, green tea extract, ascorbic acid, lysine.

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