M.W. Roomi, T. Kalinovsky, A. Niedzwiecki, M. Rath
Experimental Oncology 2009; 31(4): 214-219
The pathogenesis of hemangiomas is still largely unknown and the current therapy, such as systemic corticosteroid, vincristine, and interferon-alpha, is toxic and remains unsatisfactory. A nutrient mixture (NM) containing lysine, proline, ascorbic acid and green tea extract has shown significant anti-angiogenic and anti-tumor effect against a number of cancer cell lines. Using a mouse hemangioendothelioma model, we investigated the efficacy of NM. We also tested the effect of NM in vitro, evaluating viability, MMP secretion, invasion, morphology and apoptosis.