Others

Micronutrients in mitigating the adverse health effects of air pollution – part 2

W. Sumera, M.Sc.

Journal of Cellular Medicine and Natural Health, July 2018

 

Abstract:

Air pollution is a major environmental risk to human health and well-being. According to WHO reports in 2012, ambient (outdoor) and indoor air pollution was linked to 7 million premature deaths worldwide. Most were attributed to cardiovascular diseases (stroke and ischemic heart disease), chronic obstructive pulmonary disease (COPD), lung cancer, and acute lower respiratory infections in children. Yet, 92% of the world population lives in places that exceed the WHO air quality guidelines. On the other hand, laboratory and clinical studies indicate that a nutritious diet and/or intake of micronutrients with antioxidant, anti-inflammatory, and detoxifying properties, may ameliorate many harmful health effects caused by polluted air.

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Nutritional Deficiencies in Young People: Causes, Consequences and Strategies

M. Chatterjee, A. Niedzwiecki

Journal of Cellular Medicine and Natural Health, April 2020

 

Introduction:

Being in the ‘prime of life’, health problems of individuals ranging from teenage years to late twenties rarely cause concern. However, this stage of life can be challenging for many reasons. As young men and women push their bodies to achieve athletic, aesthetic and professional goals, they may not keep track of nutrition, follow restrictive diets and develop undiagnosed nutritional deficiencies.

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Seaweed – a substitute for ascorbic acid

V. Ivanov, S. Ivanova, A. Niedzwiecki, M. Rath

Journal of Cellular Medicine and Natural Health, June 2016

 

Abstract:

Objective: Seaweeds are an abundant and readily available source of both bulk nutrients and biologically active nutrients. We hypothesized that seaweed polysaccharide fucoidan could serve as a temporary substitute for ascorbic acid under conditions of vitamin C deficiency by beneficially affecting structural properties of the arterial wall.Methods: This was tested in an experimental model of cultured smooth muscle cells (AoSMC) and endothelial cells (AoEC) isolated from human aorta and cultured dermal fibroblasts (DFB) isolated from human skin. The effects of fucoidan in cultured cells were characterized by immunochemical assessment of deposition of selected extracellular matrix (ECM) proteins and glycosaminoglycans. Results: Physiological concentrations of fucoidan effectively stimulated ECM deposition of proteins, presented by collagen types I and IV, and glycosaminoglycans, presented by heparan sulfate and hyaluronic acid, by AoSMC and DFB in manner and extent comparable to corresponding actions of ascorbic acid. Activity of a combination of two nutrients did not exceed activity of the compounds applied individually. Neither fucoidan nor ascorbic acid modulated ECM components deposition by AoEC under used experimental conditions. Structural characteristics of ECM components deposited by cultured cells under influence of fucoidan remain a subject of future research. Conclusion: The results support our initial hypothesis on a capacity of seaweed sulfated polysaccharide fucoidan to possess vitamin C-like activity on ECM components production and deposition by arterial wall resident cells.

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Health-related assessment of a vitamin and mineral supplement in school age children

V.Korzun, S.Gpzak, A.Parats, V. Ivanov, A. Niedzwiecki, M. Rath

Journal of Cellular Medicine and Natural Health, June 2016

 

Abstract:

Objective: Study of the effect of a vitamin-mineral complex, Vitacor Junior, on children’s health, physical development and learning performance. Methods: Children attending the grammar school in the Zhytomyr region received one tablet daily of a vitamin-mineral complex with school meals (n = 69, the vitamin group) while children in the control group (n = 34) received only their regular school meals. Evaluation of the children was carried out before and after seven months of supplement intake.Results: After seven months, children in the vitamin group had improved functional status of their muscular and cardiac-respiratory systems and showed a decrease in the incidence and likelihood of acute forms of illnesses. Average level of acute morbidity was decreased by 25.5 % (from 1.83 ± 0.13 to 1.37 ± 0.13 incidents per year, t = 2.44; p < 0.05) compared to the similar index before taking the supplements. The reduction of the probability of two to four acute illnesses in the year was decreased by 2.83 % (RR = 2.83; 95 % CI 1.46-5.49; EF = 64.7 %). Functional status of the cardio-respiratory systems assessed by Skibinski index was improved by 28.2 % (from 5.82 ± 0.42 to 7.46 ± 0.57, t = 2.29; p < 0.05), and diastolic blood pressure and heart rate decreased from t = -3.64; p < 0.001 to t =-2.43; p < 0.05, respectively. Functional status of the muscular system based on the indicator of the strength of hand muscles was improved by 16.2 % (t = 2.15; p <0.05) and based on evaluation of the power index (χ2 = 16.33; p < 0.01). It is established that the proportion of children with low adaptation body reserve opportunities in the control group tends to increase (y = 18.2, x – 0.1), however in the vitamin group it tends to decrease (y = -7.2, x + 49.2).Conclusions: Daily intake of a vitamin-mineral complex contributed to the improvement of the health status of children and it should be recommended for use in children’s nutrition.

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Comparison of the antioxidant efficacy and cellular protection by several categories of nutritional supplements on the market

M. Chatterjee, S. Ivanova, V. Ivanov, A. Niedzwiecki, M. Rath

Journal of Cellular Medicine and Natural Health, June 2016

 

Oxidative stress is a common source of cellular damage that is implicated in many diseases. Many people use nutritional supplements to maintain and improve their health. However, there is little information on how, or even if, popular dietary supplements improve cellular health by protecting the body from oxidative stress. Our study tests popular dietary supplements from the European and US markets in a uniform, standardized manner. This allows us to better understand how the differences in supplement compositions and/or ingredient doses may affect their efficacy at cellular level. The results show large differences in cellular efficacy of supplements even within the same category. Consistently, products containing ingredients chosen on the basis of their synergy confer greater protection from oxidative stress.

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Hair growth stimulating effect of a nutrient mixture in athymic nude mice

M. W. Roomi, T. Kalinovsky, A. Niedzwiecki, M. Rath

Journal of Cellular Medicine and Natural Health, June 2016

 

Alopecia, a common, distressing occurrence in humans also occurs in rodents. Our main objective in this study was to examine the effects of a mixture of nutrients containing ascorbic acid, lysine, proline and green tea extract on hair growth in nude mice, since they are genetically predisposed to pattern balding. Prior to testing the nutrients on nude mice, we studied the effect of NM by diet and topical application on hair growth in shaved dorsal region of Swiss mice. Following one week of isolation, dorsal hairs were shaved with an electric shaver (3 x 2 cm) and removed from shaved area with PBS.

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Micronutrients in mitigating the adverse health effects of air pollution

W. Sumera

Journal of Cellular Medicine and Natural Health, Sept 2017

 

Air pollution is a major environmental risk to human health and wellbeing. According to WHO reports in 2012, ambient (outdoor) and indoor air pollution was linked to seven million premature deaths worldwide. Most of them were attributed to cardiovascular diseases (stroke and ischemic heart disease), chronic obstructive pulmonary disease (COPD), lung cancer, and acute lower respiratory infections in children. Yet 92% of the world population lives in places that exceed the WHO air quality guidelines. On the other hand, laboratory and clinical studies indicate that a nutritious diet and/or intake of micronutrients with antioxidant, anti-inflammatory, and detoxifying properties may ameliorate many harmful health effects caused by polluted air.

This review is composed of two parts: Part I addresses cellular and health aspects associated with human exposure to polluted air and Part II (to be published in the next edition of our Journal) will discuss potential biological mechanisms underlying the protective effects of vitamins B, C, and E, omega-3 fatty acids, and sulforaphane against air pollutants, as demonstrated in human studies.

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Natural nutrient mixture effectively reduces collagen matrix contraction driven by human uterine smooth muscle cells

V. Ivanov, M.W. Roomi, T. Kalinovsky, A. Niedzwiecki, M.Rath
Journal of Obstetrics and Gynaecology Research 2006, 32(1): 23-31

Aim
Abnormal uterine myometrial contractility causes preterm delivery, contributing to perinatal morbidity and mortality. Disturbances in hormonal regulation and inflammation-related processes have been attributed a role in the pathophysiological mechanisms of uterine contractility. We investigated the effects of natural nutrients on uterine tissue contractility in vitro.

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The effect of PEG-coated gold nanoparticles on the anti-proliferative potential of Specific Nutrient Synergy

S. Harakeh, R.M. Abdel-Maih, P.R. Gil, R.A Sperling, A. Meinhardt, A. Niedzwiecki, M. Rath, W.J. Parak, E. Baydoun
Nanotoxicology 2010; 4:177-85

Abstract:
The role of PEG-coated gold nanoparticles (Au NPs) on the anti-proliferative effect of Specific Nutrient Synergy (SNS) on HTLV-1 infected (C91-PL and HuT-102) and non-infected (CEM and Jurkat) malignant T-lymphocytes cells, was investigated. When PEG-coated Au NPs (of different molecular weights) were added alone, there was no effect on either viability or proliferation of the leukemic cell lines studied.

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Efficacy of nutritional treatment in patient with psoriasis: A case report

1Natural Harmony, 47301 Petaling Jaya, Selangor, Malaysia    
2Dr. Rath Research Institute, 1260 Memorex Drive, Santa Clara, CA 95050
Experimental & Therapeutic Medicine 2015, DOI: 10.3892/etm.2015.2631

Abstract:

Psoriasis is a chronic inflammatory skin disease characterized by thickened, silvery scaled patches. There is currently no cure and treatments only attempt to reduce the severity of symptoms. This study reports the case of a 36 year old female who presented to the clinic with severe psoriasis and had been treated with topical steroid cream for the past 14 years.

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