Enhancement of Cardio-Protective Effects and Attenuation of Adverse Effects of Female Sex Hormones on Cultured Human Vascular Smooth Muscle Cells by a Combination of Ascorbic Acid, Lysine, Proline, Arginine, Cysteine and Epigallocatechin Gallate

Ivanov V, Ivanova S, Roomi MW, Netke SP, Niedzwiecki A, Rath M

Presented at: 
6th European Congress of Endocrinology, Lyon, France, April 26-30, 2003.

Published in: 
The Abstract Book by the European Federation of Endocrine Societies, Abstract #P0750, 2003.



Large numbers of menopausal women are using hormone replacement therapy (HRT) for counteracting such adverse effects as hot flashes and loss of bone mass. However, HRT has been recently shown to have major adverse effects on cardiovascular health. When tested in an experimental system of cultured human vascular smooth muscle cells, female sex hormones produced diverse effects on atherogenic changes in smooth muscle cells properties such as pathologically increased growth rate and invasiveness and excessive production of extracellular matrix components and inflammatory SW. Nutrient Synergy enhanced the cardio-protective action of female sex hormones and counteracted their adverse effects in these experimental conditions, suggesting that it has great potential as an adjunctive therapeutic agent in inhibiting adverse effects and enhancing the cardio-protective effects of female sex hormones in HRT.