Jariwalla RJ, Roomi MW, Kalinovsky T, Rath M, Niedzwiecki A
In: Global View of the Fight Against Influenza, edited by Petar Mitrasinovic, Nova Publishers, 2009
Influenza remains a major health threat among infectious diseases, affecting a fifth of the world’s population. Current vaccines and drugs have limited efficacy and there is an urgent need for effective therapies. Influenza virus A not only infects susceptible (alveolar) cells in the lungs, but also manifests in extrapulmonary areas, which require basement membrane disruption by matrix metalloproteinases (MMPs) capable of degrading collagen type IV.